Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282378 | 0.87 | AR (0.45) | GAAPOLBGFERARALDH1A1 | |
| SCHEMBL282452 | 0.75 | GAA (0.43) | GAAPOLBGFERARMAPT | |
| SCHEMBL18723690 | 0.73 | TDP1 (0.47) | GAAARTYMSDHFRMAPT | |
| SCHEMBL20780317 | 0.73 | GAA (0.47) | GAAPOLBGFERALDH1A1HPGD | |
| SCHEMBL282017 | 0.72 | THRB (0.53) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL2973838 | 0.72 | GAA (0.52) | GAAPOLBGFERMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8800518 | 0.71 | THRB (0.52) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL6864460 | 0.71 | THRB (0.48) | GAAPOLBGFERMAPTKDM4E | |
| SCHEMBL6690378 | 0.71 | THRB (0.36) | GAAPOLBGFERARTYMS | |
| SCHEMBL7353139 | 0.70 | THRB (0.40) | MAPTKDM4EP2RX3P2RX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723717-B1 | CARDIAC-SPARING; SIDE EFFECT REDUCTION | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2004-04-20 | — | — | US | disclosed |