Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114452 | 0.87 | THRB (0.50) | THRBGAAPOLBGFERTHRA | |
| SCHEMBL282125 | 0.87 | THRB (0.47) | THRBGAAPOLBGFERTHRA | |
| SCHEMBL666032 | 0.86 | THRB (0.43) | THRBGAAPOLBGFERTHRA | |
| SCHEMBL282445 | 0.86 | THRB (0.49) | THRBTHRACA2OPRK1 | |
| SCHEMBL667473 | 0.80 | THRB (0.45) | THRBTHRAALDH1A1OPRK1 | |
| SCHEMBL27702889 | 0.79 | THRB (0.64) | THRBTHRA | |
| SCHEMBL7590192 | 0.79 | ALDH1A1 (0.43) | THRBGAATHRAALDH1A1KDM4E | |
| SCHEMBL667776 | 0.79 | THRB (0.39) | THRBGAAPOLBGFERTHRA | |
| SCHEMBL6864242 | 0.79 | THRB (0.49) | THRBTHRAOPRK1KDM4E | |
| SCHEMBL7599524 | 0.77 | THRB (0.47) | THRBTHRAOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286957-B1 | DIPHENYLMETHANE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-11-03 | — | — | EP | disclosed |
| US-6803480-B2 | THERAPEUTIC TREATMENT AND/OR PROPHYLAXIS OF ARTERIOSCLEROSIS AND HYPERCHOLESTEROLAEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 2004-10-12 | — | — | US | disclosed |
| US-20030203898-A1 | Therapeutic treatment and/or prophylaxis of arteriosclerosis and hypercholesterolaemia | BAYER AKTIENGESELLSCHAFT (DE) | 2003-10-30 | — | — | US | disclosed |
| EP-1286957-A1 | DIPHENYLMETHANE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001090053-A1 | DIPHENYLMETHANE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203898-A1 | Therapeutic treatment and/or prophylaxis of arteriosclerosis and hypercholesterolaemia | APOB, HMGCR, PCSK9 | THRB 2653/4885GAA 1550/4885POLB 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.