SCHEMBL6765978

SCHEMBL6765978

CSc1nc(Nc2ccc3nc(C)cc(N)c3c2)nc(Nc2ccc3nc(C)cc(N(C)C)c3c2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TERT O14746 18/20 1.00
DOT1L Q8TEK3 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4077093 0.93 TERT (0.86) TERTDOT1L
SCHEMBL6765226 0.93 TERT (1.00) TERTDOT1L
SCHEMBL5630421 0.87 TERT (0.88) TERTDOT1L
SCHEMBL6765942 0.86 TERT (0.86) TERTDOT1L
SCHEMBL5630261 0.85 TERT (0.76) TERTDOT1L
SCHEMBL5631618 0.85 TERT (0.84) TERTDOT1L
SCHEMBL4074842 0.84 TERT (0.91) TERTDOT1L
SCHEMBL7250482 0.83 TERT (0.72) TERTDOT1L
SCHEMBL6344443 0.82 TERT (0.69) TERTDOT1L
SCHEMBL7255812 0.81 TERT (0.70) TERTDOT1L

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040053966-A1 Chemical derivatives and their application as antitelomerase agent AVENTIS PHARMS S.A. 2004-03-18 US claimed
US-6645964-B1 1,3,5-Triazine compounds substituted with aromatic N-heterocycle; anticarcinogenic agents AVENTIS PHARMA S.A. (FR) 2003-11-11 US claimed
EP-1244650-B1 ARYLAMINE DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT AVENTIS PHARMA SA (FR) 2003-06-25 EP claimed
EP-1244650-A1 ARYLAMINE DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT Aventis Pharma S.A. (FR) 2002-10-02 EP claimed
WO-2001040218-A1 ARYLAMINE DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT AVENTIS PHARMA S.A. (FR) 2001-06-07 WO claimed
US-20040053966-A1 Chemical derivatives and their application as antitelomerase agent AVENTIS PHARMS S.A. 2004-03-18 US disclosed
US-6645964-B1 1,3,5-Triazine compounds substituted with aromatic N-heterocycle; anticarcinogenic agents AVENTIS PHARMA S.A. (FR) 2003-11-11 US disclosed
EP-1244650-B1 ARYLAMINE DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT AVENTIS PHARMA SA (FR) 2003-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040053966-A1 Chemical derivatives and their application as antitelomerase agent NTPCR, DPYD, NME1 TERT 168/4885DOT1L 1387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.