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SCHEMBL6344443

SCHEMBL6344443

Cc1cc(N)c2cc(Nc3nc(Nc4ccc5nc(C)cc(N(C)C)c5c4)nc(Nc4ccccc4Cl)n3)ccc2n1

nearest known ligand 0.69

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ TERT O14746 16/20 0.69
▸ DOT1L Q8TEK3 2/20 0.55
▸ APAF1 O14727 1/20 0.48
▸ USP2 O75604 1/20 0.48
▸ POLB P06746 1/20 0.48
▸ MAPT P10636 1/20 0.48
▸ MAPK1 P28482 1/20 0.48
▸ UBE2N P61088 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4077093 0.88 TERT (0.86) TERTDOT1LKMT2A
SCHEMBL6335955 0.87 TERT (0.61) TERTDOT1LAPAF1USP2POLB
SCHEMBL6345682 0.85 TERT (0.54) TERTDOT1LAPAF1USP2POLB
SCHEMBL6347593 0.84 TERT (0.53) TERTDOT1LAPAF1USP2POLB
SCHEMBL6765978 0.82 TERT (1.00) TERTDOT1L
SCHEMBL4076919 0.80 TERT (1.00) TERTDOT1LMAPTMAPK1KMT2A
SCHEMBL4074842 0.80 TERT (0.91) TERTDOT1LKMT2A
SCHEMBL6340164 0.80 TERT (0.52) TERTDOT1LAPAF1USP2POLB
SCHEMBL4077105 0.79 TERT (0.97) TERTDOT1L
SCHEMBL6339837 0.78 TERT (0.78) TERTDOT1LKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6887873-B2 Triazine derivatives and their application as antitelomerase agents AVENTIS PHARMA S.A. (FR) 2005-05-03 — — US claimed