Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050896 | 1.00 | LMNA (0.32) | LMNAMAPTMAPK14 | |
| SCHEMBL6763644 | 1.00 | LMNA (0.32) | LMNAMAPTMAPK14 | |
| SCHEMBL245938 | 0.86 | MAPT (0.43) | LMNAMAPTMAPK14 | |
| SCHEMBL241718 | 0.84 | — | — | |
| SCHEMBL23628544 | 0.82 | — | — | |
| SCHEMBL1438735 | 0.82 | — | — | |
| SCHEMBL27838898 | 0.79 | NOTUM (0.52) | LMNAMAPTMAPK14 | |
| SCHEMBL14080751 | 0.79 | NOTUM (0.52) | LMNAMAPTMAPK14 | |
| SCHEMBL8187863 | 0.76 | NPC1 (0.40) | LMNAMAPTMAPK14 | |
| SCHEMBL9582303 | 0.76 | RPS6KA3 (0.43) | LMNAMAPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730666-B1 | INHIBITION OF GROWTH FACTOR TYROSINE KINASE RECEPTOR ACTIVITY, PARTICULARLY INHIBITION OF ANGIOGENESIS AND RELATED DISORDERS, TUMOR PROGRESSION AND GROWTH FACTOR RELATED SKELETAL DISORDERS, BY PORPHYRIN AND CORROLE COMPOUNDS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-05-04 | — | — | US | disclosed |