Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766212 | 1.00 | CHRM2 (0.49) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL2306567 | 0.83 | CHRM2 (0.54) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL6761061 | 0.81 | CHRM2 (0.55) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL6761062 | 0.81 | CHRM2 (0.55) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL6781026 | 0.81 | NPC1 (0.56) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL29216353 | 0.78 | KMT2A (0.47) | ALDH1A1MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL11334883 | 0.76 | SIRT1 (0.74) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL8967852 | 0.74 | NR4A1 (0.60) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL15284800 | 0.73 | SIRT1 (0.47) | CHRM2CHRM1CHRM3SIRT1HDAC1 | |
| SCHEMBL6763132 | 0.73 | CHRM2 (0.40) | CHRM2CHRM1CHRM3SLC6A9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | CHRM2 624/4885CHRM1 274/4885CHRM3 843/4885 |
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | CHRM2 624/4885CHRM1 274/4885CHRM3 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.