Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | THPO | P40225 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.60 |
| ▸ | PTGER1 | P34995 | 8/20 | 0.57 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL11827760 | 0.97 | MEN1 (0.66) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9273344 | 0.90 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6969652 | 0.89 | MEN1 (0.69) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8115609 | 0.89 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9172696 | 0.88 | MEN1 (0.65) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9400122 | 0.86 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9174371 | 0.85 | MEN1 (0.61) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9275497 | 0.85 | MEN1 (0.54) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9857831 | 0.85 | ALDH1A1 (0.73) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9185113 | 0.85 | MAPT (0.64) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911331-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2003-10-22 | — | — | EP | claimed |
| EP-0694546-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and use | SEARLE & CO (US) | 2001-06-06 | — | — | EP | claimed |
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | claimed |
| EP-0583421-B1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1999-06-16 | — | — | EP | claimed |
| EP-0911331-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1999-04-28 | — | — | EP | claimed |
| EP-0512400-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 1998-12-02 | — | — | EP | claimed |
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | claimed |
| EP-0694545-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | claimed |
| EP-0694546-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | claimed |
| US-5464830-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1995-11-07 | — | — | US | claimed |
| WO-1992019605-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G. D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | claimed |
| EP-0193822-B1 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | claimed |
| US-4704386-A | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides | G. D. SEARLE & CO. (US) | 1987-11-03 | — | — | US | claimed |
| US-4681939-A | 8-chlorodibenz[b,f][1,4]oxazepine-10-(11H)-carboxylic acid, 2-[(phenylthio)alkanoyl]hydrazides | G. D. SEARLE & CO. (US) | 1987-07-21 | — | — | US | claimed |
| EP-0218077-A1 | 8-Chlorodibenz[b,f] [1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylthio-, phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides | G.D. Searle & Co. (US) | 1987-04-15 | — | — | EP | claimed |
| US-4614617-A | Intermediates for 8-chlorodibenz[(b,f)][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G. D. SEARLE & CO. (US) | 1986-09-30 | — | — | US | claimed |
| EP-0193822-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-10 | — | — | EP | claimed |
| EP-0193148-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-03 | — | — | EP | claimed |
| US-4559337-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | claimed |
| US-4559336-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | claimed |