Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9273344 | 0.90 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9262722 | 0.89 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL676665 | 0.89 | MEN1 (0.69) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Hydrazine SCHEMBL11827760 | 0.87 | MEN1 (0.66) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10717820 | 0.85 | ALDH1A1 (0.60) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8788236 | 0.84 | HSD17B3 (0.53) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9400122 | 0.84 | MEN1 (0.56) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9399959 | 0.79 | MAPT (0.51) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6969652 | 0.78 | MEN1 (0.69) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9172696 | 0.78 | MEN1 (0.65) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5461046-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| US-5393747-A | Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E2 antagonists | G. D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5304644-A | 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain | G. D. SEARLE & CO. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0583408-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |
| US-5283240-A | Administering prostaglandin antagonists | G. D. SEARLE & CO. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5182272-A | 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain | G. D. SEARLE & CO. (US) | 1993-01-26 | — | — | US | disclosed |
| WO-1992019605-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G. D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512399-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |