Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TKT | P29401 | 7/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070440 | 0.85 | TKT (0.44) | ALDH1A1MAPTMEN1KMT2APLA2G1B | |
| Bromide SCHEMBL3846652 | 0.84 | OPRM1 (0.45) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL5015366 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HTTMAPTMEN1KMT2A | |
| Bromide SCHEMBL3846487 | 0.80 | HTT (0.53) | ALDH1A1HTTMAPTMEN1KMT2A | |
| SCHEMBL5070441 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HTTL3MBTL1MAPTMEN1 | |
| Bromide SCHEMBL3852034 | 0.75 | OPRM1 (0.42) | ALDH1A1HTTL3MBTL1MAPTMEN1 | |
| Bromide SCHEMBL3846651 | 0.75 | HTT (0.48) | ALDH1A1HTTL3MBTL1MAPTMEN1 | |
| Bromide SCHEMBL5015370 | 0.74 | KMT2A (0.39) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| Bromide SCHEMBL3852040 | 0.70 | HTT (0.45) | ALDH1A1HTTMAPTMEN1KMT2A | |
| SCHEMBL5015364 | 0.69 | KMT2A (0.56) | ALDH1A1HTTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790859-B2 | THERAPY OR REDUCING PROGRESSION OF HYPERTENSION OR DAMAGE TO A TISSUE CAUSED BY CONTACT WITH ELEVATED LEVELS OF REDUCING SUGARS IN AN ANIMAL, COMPRISING ADMINISTERING TO THE ANIMAL AN EFFECTIVE AMOUNT OF THIAZOLIUM COMPOUNDS | ALTEON INCORPORATED | 2004-09-14 | — | — | US | claimed |