Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487819 | 0.85 | TGFBR1 (0.50) | TSHRTGFBR1ALDH1A1RXFP1TDP1 | |
| SCHEMBL636063 | 0.85 | TSHR (0.71) | TSHRALDH1A1CYP2C19MAPK1TDP1 | |
| SCHEMBL6015992 | 0.84 | TSHR (0.72) | TSHRTGFBR1ALDH1A1CYP2C19RXFP1 | |
| SCHEMBL7996057 | 0.81 | TSHR (0.40) | TSHRTGFBR1 | |
| SCHEMBL28281570 | 0.80 | TSHR (0.48) | TSHRTGFBR1ALDH1A1CYP2C19RXFP1 | |
| SCHEMBL28518754 | 0.79 | TSHR (0.62) | TSHRALDH1A1CYP2C19MAPK1TDP1 | |
| SCHEMBL7632867 | 0.78 | TSHR (0.37) | TSHRTGFBR1 | |
| SCHEMBL7133791 | 0.77 | TSHR (0.67) | TSHRTGFBR1ALDH1A1CYP2C19RXFP1 | |
| SCHEMBL3901758 | 0.76 | TSHR (0.65) | TSHRALDH1A1CYP2C19MAPK1TDP1 | |
| SCHEMBL24150307 | 0.75 | TSHR (0.48) | TSHRALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6726905-B1 | LOWERING SERUM PHOSPHATE | GENZYME CORPORATION | 2004-04-27 | — | — | US | disclosed |