Ym-60828

Ym-60828

SCHEMBL676753

CC(=N)N1CCC(Oc2ccc(N(Cc3ccc4ccc(C(=N)N)cc4c3)S(=O)(=O)CC(=O)O)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 1.00
F2 P00734 2/20 1.00
KCNH2 Q12809 1/20 0.82
PRSS1 P07477 3/20 0.59
PLG P00747 2/20 0.58
PRSS2 P07478 2/20 0.58
PRSS3 P35030 2/20 0.58
PLAT P00750 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ym-60828 SCHEMBL29374349 1.00 F10 (1.00) F10F2KCNH2PRSS1PLG
Ym-60828 SCHEMBL29374786 1.00 F10 (1.00) F10F2KCNH2PRSS1PLG
Ym-60828 SCHEMBL6158242 0.99 F10 (0.98) F10F2KCNH2PRSS1PLG
Ym-60828 SCHEMBL30693688 0.98 F10 (0.95) F10F2KCNH2PRSS1PLG
SCHEMBL20248862 0.95 F10 (0.90) F10F2KCNH2PRSS1PLG
Hydrochloric Acid SCHEMBL6954901 0.94 F10 (0.90) F10F2KCNH2PRSS1PLG
SCHEMBL19699428 0.92 F10 (0.85) F10F2KCNH2PRSS1PLG
Hydrochloric Acid SCHEMBL6959811 0.92 F10 (0.85) F10F2KCNH2PRSS1PLG
Hydrochloric Acid SCHEMBL8801687 0.92 F10 (0.84) F10F2KCNH2PRSS1PLG
SCHEMBL19691082 0.92 F10 (0.84) F10F2KCNH2PRSS1PLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240424175-A1 ANTICOAGULANT COMPOUNDS COMPRISING CHELATING AGENTS AND CATIONIC ANTI-COAGULATION ENHANCERS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2024-12-26 US claimed
US-11654036-B2 Anticoagulant compounds and methods and devices for their use ELIXIR MEDICAL CORPORATION (US) 2023-05-23 US claimed
US-20220039976-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2022-02-10 US claimed
WO-2006110726-A2 DOSAGE FORMULATIONS AND METHODS OF TREATMENT AND PREVENTION GLAXO GROUP LIMITED (GB) 2006-10-19 WO claimed
US-20050187249-A1 An aqueous solution of a physiologically active substance which may have a substituent and which has an amidino group, the solution having a pH > 2 and -/< than 4; storage stability; parental injections; 2-[4-[((3S)-1-acetoimidoyl-3-pyrrolidinyl)oxy]phenyl] -3-(7-amidino-2-naphthyl)propionic acid; kits DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-08-25 US claimed
EP-1504755-A1 LYOPHILIZATION PRODUCT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-02-09 EP claimed
EP-0798295-B1 NOVEL AMIDINONAPHTHYL DERIVATIVE OR SALT THEREOF YAMANOUCHI PHARMA CO LTD (JP) 2003-02-26 EP claimed
EP-1043020-A1 MEDICINAL COMPOSITION FOR PERCUTANEOUS ADMINISTRATION DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-10-11 EP claimed
EP-0966973-A1 SORBEFACIENTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-12-29 EP claimed
EP-0953359-A1 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-11-03 EP claimed
EP-0798295-A1 NOVEL AMIDINONAPHTHYL DERIVATIVE OR SALT THEREOF YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1997-10-01 EP claimed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 US disclosed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 US disclosed
US-20230165874-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR PULMONARY USE ELIXIR MEDICAL CORPORATION (US) 2023-06-01 US disclosed
WO-2023096800-A1 ANTICOAGULANT COMPOUNDS COMPRISING CHELATING AGENTS AND CATIONIC ANTI-COAGULATION ENHANCERS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2023-06-01 WO disclosed
EP-1110556-A1 PREVENTIVES/REMEDIES FOR MULTIPLE ORGAN FAILURE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-27 EP disclosed
EP-1043020-A1 MEDICINAL COMPOSITION FOR PERCUTANEOUS ADMINISTRATION DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-10-11 EP disclosed
EP-0966973-A1 SORBEFACIENTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-12-29 EP disclosed
EP-0953359-A1 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-11-03 EP disclosed
EP-0798295-A1 NOVEL AMIDINONAPHTHYL DERIVATIVE OR SALT THEREOF YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1997-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 ACE2, SARS1, ACE F10 4535/4885F2 660/4885KCNH2 3957/4885
US-20050187249-A1 An aqueous solution of a physiologically active substance which may have a substituent and which has an amidino group, the solution having a pH > 2 and -/< than 4; storage stability; parental injections; 2-[4-[((3S)-1-acetoimidoyl-3-pyrrolidinyl)oxy]phenyl] -3-(7-amidino-2-naphthyl)propionic acid; kits NGLY1, IDE, NPPA F10 98/4885F2 457/4885KCNH2 1792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.