Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766363 | 0.89 | CYP2D6 (0.47) | CYP2D6MAOBKMT2AMEN1PDE3B | |
| SCHEMBL6766920 | 0.86 | CYP2D6 (0.53) | CYP2D6MAOBKMT2AMEN1PDE3B | |
| SCHEMBL6763578 | 0.83 | CYP2D6 (0.50) | CYP2D6MAOBKMT2AMEN1PDE3B | |
| SCHEMBL6766369 | 0.83 | KCNN4 (0.43) | KMT2AMEN1PDE3BPDE3AALDH1A1 | |
| SCHEMBL6763490 | 0.82 | CYP2D6 (0.54) | CYP2D6MAOBKMT2AMEN1HSP90AA1 | |
| SCHEMBL5778171 | 0.78 | MEN1 (0.39) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL6766166 | 0.77 | CYP2D6 (0.40) | CYP2D6MAOBKMT2AMEN1MAPT | |
| SCHEMBL5780812 | 0.76 | HTR7 (0.42) | MAOBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6765889 | 0.75 | HTR7 (0.41) | MAOBKDM4EALDH1A1 | |
| SCHEMBL5780821 | 0.73 | KDM4E (0.48) | CYP2D6MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |