Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767752 | 0.95 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6773099 | 0.94 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL6766624 | 0.92 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6766471 | 0.91 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6764212 | 0.91 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6763885 | 0.89 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6632918 | 0.88 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6767002 | 0.86 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11PDE10A | |
| SCHEMBL6632387 | 0.86 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6621979 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | claimed |
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2003-12-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | IL1B, IL1A, IL1R1 | MAPK14 1086/4885MAPK13 1053/4885MAPK12 997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.