Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ganomycin B SCHEMBL30164283 | 1.00 | BACE1 (0.65) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin B SCHEMBL6764577 | 1.00 | BACE1 (0.65) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin B SCHEMBL7074168 | 1.00 | BACE1 (0.65) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin B SCHEMBL12249396 | 1.00 | BACE1 (0.65) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin A SCHEMBL6765493 | 0.92 | PTGS2 (0.67) | BACE1PTGS2ACHECTSKALOX5 | |
| SCHEMBL6764548 | 0.92 | PTGS2 (0.67) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin A SCHEMBL7074132 | 0.92 | PTGS2 (0.67) | BACE1PTGS2ACHECTSKALOX5 | |
| SCHEMBL6761207 | 0.92 | PTGS2 (0.67) | BACE1PTGS2ACHECTSKALOX5 | |
| Ganomycin A SCHEMBL1839019 | 0.92 | PTGS2 (0.67) | BACE1PTGS2ACHECTSKALOX5 | |
| SCHEMBL6764592 | 0.91 | BACE1 (0.54) | BACE1PTGS2ACHECTSKALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6726911-B1 | SOLVENT EXTRACT; MICROBIOCIDES; ENDOPEPTIDASE, ANGIOTENSIN CONVERTING ENZYME AND SERUM-MEDIATED-BINDING OF LIPOPOLYSACCHARIDE INHIBITORS | GANOMYCIN (DE) | 2004-04-27 | — | — | US | disclosed |
| EP-1158995-B1 | BIOLOGICALLY ACTIVE COMPOUNDS OF GANODERMA PFEIFFERI DMS 13239 | GANOMYCIN GES FUER BIOMEDIZINI (DE) | 2003-06-18 | — | — | EP | disclosed |