Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 8/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28664582 | 0.79 | ALDH1A1 (0.35) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL30083014 | 0.79 | ALDH1A1 (0.35) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL15902847 | 0.78 | MAPK1 (0.51) | MAPTSMN1; SMN2HPGDLMNATDP1 | |
| SCHEMBL29965642 | 0.77 | MAPK1 (0.39) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL23663468 | 0.77 | MAPK1 (0.39) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL5327698 | 0.77 | RORC (0.62) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL7590825 | 0.76 | MAPK1 (0.47) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL2962266 | 0.75 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2HPGDNPC1CYP1A2 | |
| SCHEMBL2036320 | 0.73 | ALDH1A1 (0.50) | MAPTSMN1; SMN2HPGDCYP3A4LMNA | |
| SCHEMBL2033024 | 0.73 | PDE7A (0.49) | MAPTSMN1; SMN2RAB9ALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723717-B1 | CARDIAC-SPARING; SIDE EFFECT REDUCTION | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2004-04-20 | — | — | US | disclosed |