Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | PRKCI | P41743 | 2/20 | 0.57 |
| ▸ | F10 | P00742 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3902353 | 0.99 | SMN1; SMN2 (0.61) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL5395436 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL12857647 | 0.84 | PRKCI (0.75) | SMN1; SMN2RAB9ANPC1HTTKMT2A | |
| SCHEMBL30338953 | 0.83 | NPC1 (0.70) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL890674 | 0.83 | NPC1 (0.70) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL3901503 | 0.81 | GRM4 (0.60) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL6108569 | 0.81 | RAB9A (0.63) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL6772756 | 0.80 | GRM5 (0.62) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL27556949 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALOX15RAB9ANPC1HTT | |
| SCHEMBL2397278 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALOX15RAB9ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105436-A1 | Lactam-containing compounds and derivatives thereof as factor XA inhibitors | Bristol-Myers Squibb Company (US) | 2009-09-30 | — | — | EP | disclosed |
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1140905-A1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039117-A1 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |