Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 3/20 | 0.54 |
| ▸ | ATR | Q13535 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29837506 | 0.89 | L3MBTL1 (0.66) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL28764679 | 0.89 | L3MBTL1 (0.66) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL5205251 | 0.85 | L3MBTL1 (0.57) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL18070988 | 0.85 | L3MBTL1 (0.60) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL29738591 | 0.84 | KMT2A (0.60) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL29738593 | 0.84 | KMT2A (0.60) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL3001084 | 0.84 | KMT2A (0.60) | L3MBTL1RAB9ANPC1KMT2ABRD4 | |
| SCHEMBL3901503 | 0.83 | GRM4 (0.60) | GRM5L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL13923493 | 0.82 | SMN1; SMN2 (0.61) | GRM5L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL6769262 | 0.80 | SMN1; SMN2 (0.63) | L3MBTL1RAB9ANPC1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1140905-A1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039117-A1 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |