Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632497 | 0.80 | QPCT (0.83) | QPCTALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL26622950 | 0.77 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL31668680 | 0.77 | MAOB (0.88) | MAPTNPC1RAB9AMAOBMAOA | |
| SCHEMBL5506600 | 0.76 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL5445694 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL22621288 | 0.75 | GPR174 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL13805297 | 0.75 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL5610878 | 0.74 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL20774545 | 0.74 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL5448009 | 0.73 | KMT2A (0.79) | ALDH1A1SMN1; SMN2HPGDMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750242-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2004-06-15 | — | — | US | claimed |
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | claimed |
| US-6750242-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2004-06-15 | — | — | US | disclosed |
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |