SCHEMBL676964

SCHEMBL676964

O=C(/C=C/c1c(O)cc(O)cc1O)c1ccc(O)cc1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.70
NFKB1 P19838 3/20 0.70
MEN1 O00255 3/20 0.70
KMT2A Q03164 3/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2C19 P33261 2/20 0.70
MAPT P10636 2/20 0.70
HPGD P15428 2/20 0.70
TDP1 Q9NUW8 2/20 0.70
ALOX15 P16050 2/20 0.70
MAPK1 P28482 2/20 0.70
HSD17B10 Q99714 2/20 0.70
AKR1B1 P15121 2/20 0.70
CHRNA7 P36544 2/20 0.70
HSD17B2 P37059 2/20 0.70
NFKB2 Q00653 2/20 0.70
RELA Q04206 2/20 0.70
BACE1 P56817 2/20 0.70
TYR P14679 1/20 0.70
GMNN O75496 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL676965 1.00 CYP3A4 (0.70) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL28035028 0.90 BACE1 (0.70) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL11068223 0.85 CYP3A4 (0.72) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL11068235 0.85 CYP3A4 (0.72) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL17988249 0.84 MEN1 (0.78) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL27810313 0.84 MEN1 (0.78) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL25208375 0.84 MEN1 (0.96) CYP3A4NFKB1MEN1KMT2ACYP2C9
Isoliquiritigenin SCHEMBL10408923 0.82 CYP3A4 (1.00) CYP3A4NFKB1MEN1KMT2ACYP2C9
SCHEMBL675094 0.82 TYR (1.00) CYP3A4NFKB1MEN1KMT2ACYP2C9
Isoliquiritigenin SCHEMBL161168 0.82 CYP3A4 (1.00) CYP3A4NFKB1MEN1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190142940-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2019-05-16 US disclosed
US-9744237-B2 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2017-08-29 US disclosed
US-20120207809-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2012-08-16 US disclosed
US-20120076848-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2012-03-29 US disclosed
US-20110280909-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2011-11-17 US disclosed
WO-2011011065-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2011-01-27 WO disclosed
WO-2010087983-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2010-08-05 WO disclosed