⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482343 | 0.77 | MCL1 (0.52) | — | |
| SCHEMBL670466 | 0.77 | — | — | |
| SCHEMBL18053603 | 0.77 | — | — | |
| SCHEMBL9400625 | 0.77 | MCL1 (0.46) | — | |
| SCHEMBL10958213 | 0.75 | MEN1 (0.35) | — | |
| SCHEMBL700167 | 0.73 | MCL1 (0.50) | — | |
| SCHEMBL11683228 | 0.73 | MCL1 (0.67) | — | |
| SCHEMBL11205712 | 0.73 | MCL1 (0.54) | — | |
| SCHEMBL1070231 | 0.73 | — | — | |
| SCHEMBL517963 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023641-B1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS INC (US) | 2024-05-01 | — | — | EP | claimed |
| EP-4023641-A2 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| US-9266861-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2016-02-23 | — | — | US | claimed |
| US-20150203473-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2015-07-23 | — | — | US | claimed |
| EP-2895466-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2015-07-22 | — | — | EP | claimed |
| WO-2014043706-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2014-03-20 | — | — | WO | claimed |
| CN-122036699-A | THR-beta modulators and methods of use thereof | 阿利戈斯治疗公司 | 2026-05-15 | — | — | CN | disclosed |
| EP-4658262-A1 | BICYCLIC IMIDE COMPOUNDS AS TRPA1 INHIBITORS | D.E. Shaw Research, LLC (US) | 2025-12-10 | — | — | EP | disclosed |
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2025-10-02 | — | — | US | disclosed |
| EP-4523692-A2 | MODULATORS OF THR-SS AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| EP-3965884-B1 | MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP | ALIGOS THERAPEUTICS INC (US) | 2025-01-15 | — | — | EP | disclosed |
| US-12180192-B2 | Modulators of THR-β and methods of use thereof | ALIGOS THERAPEUTICS, INC. (US) | 2024-12-31 | — | — | US | disclosed |
| WO-2024163333-A1 | BICYCLIC IMIDE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC (US) | 2024-08-08 | — | — | WO | disclosed |
| US-4952570-A | ANTIPROTOZOA AGENTS; COCCIDIOSIS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-28 | — | — | US | disclosed |
| EP-0170316-B1 | ALPHA-ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-YL)BENZENEACETONITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-05-30 | — | — | EP | disclosed |
| US-4912106-A | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5,(2H,4H)-diones and their use as protozoa combating agents | JANSSEN PHARMACEUTICA N. V. FRAME-319 (BE) | 1990-03-27 | — | — | US | disclosed |
| US-4778887-A | ANTIPROTOZOA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-10-18 | — | — | US | disclosed |
| US-4767760-A | Anti-protozoal 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione derivatives, compositions, and method of use therefor | JANSSEN PHARMACUETICA N.V. (BE) | 1988-08-30 | — | — | US | disclosed |
| EP-0232932-A1 | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-19 | — | — | EP | disclosed |
| EP-0170316-A2 | alpha-Aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitriles | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-02-05 | — | — | EP | disclosed |