Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769515 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7431115 | 0.68 | MEN1 (0.57) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7431117 | 0.68 | MEN1 (0.57) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13218488 | 0.67 | ALDH1A1 (0.52) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6769669 | 0.67 | ALDH1A1 (0.43) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14074658 | 0.65 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6765763 | 0.64 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL830681 | 0.63 | TSHR (0.55) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL835776 | 0.63 | TSHR (0.55) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL830682 | 0.63 | TSHR (0.55) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | ALDH1A1 454/4885MAPK1 3177/4885SMN1; SMN2 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.