Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770103 | 0.84 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3SIGMAR1TACR2 | |
| SCHEMBL4483285 | 0.80 | MCHR1 (0.44) | TACR2MCHR1CCR5 | |
| SCHEMBL6770099 | 0.78 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3SIGMAR1TACR2 | |
| SCHEMBL4475059 | 0.76 | ALDH1A1 (0.38) | SLC6A2SLC6A4SLC6A3MCHR1ALDH1A1 | |
| SCHEMBL6770900 | 0.74 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL6770174 | 0.73 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3SIGMAR1ALDH1A1 | |
| SCHEMBL14775196 | 0.72 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3SIGMAR1KDM4E | |
| SCHEMBL4468911 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL6770082 | 0.67 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3TACR2ALDH1A1 | |
| SCHEMBL9737250 | 0.67 | TACR2 (0.58) | SLC6A2SLC6A4SLC6A3SIGMAR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821973-B2 | ANTAGONIZE THE PHARMACOLOGICAL ACTIONS OF THE ENDOGENOUS NEUROPEPTIDE TACHYKININS KNOWN AS NEUROKININS | ASTRAZENECA AB (SE) | 2004-11-23 | — | — | US | claimed |