Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9276364 | 0.84 | NR4A2 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6772311 | 0.83 | NR4A2 (0.56) | CA12CA1CA2CA7CA9 | |
| Sulfuric Acid SCHEMBL6832154 | 0.82 | CA1 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL17912866 | 0.80 | NPC1 (0.60) | CA12CA1CA2CA7CA9 | |
| SCHEMBL14908860 | 0.77 | TSHR (0.48) | F2TSHRSMN1; SMN2PKMKMT2A | |
| SCHEMBL19766681 | 0.77 | KDM4E (0.47) | TSHRKMT2A | |
| SCHEMBL9354238 | 0.76 | LMNA (0.58) | CA12CA1CA2CA9TSHR | |
| SCHEMBL25197061 | 0.76 | DRD2 (0.65) | FFAR1SIRT2MAOAMAOBNPC1 | |
| SCHEMBL661821 | 0.76 | DRD2 (0.65) | FFAR1SIRT2MAOAMAOBNPC1 | |
| SCHEMBL28773164 | 0.76 | TSHR (0.47) | F2TSHRSMN1; SMN2PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |