Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Salicylhydroxamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.78 |
| ▸ | GAA | P10253 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | MPO | P05164 | 2/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylhydroxamic Acid SCHEMBL144849 | 0.88 | KDM4E (1.00) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL21530845 | 0.88 | KDM4E (1.00) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL7072582 | 0.86 | KDM4E (0.95) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL28791696 | 0.86 | KDM4E (0.95) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL29623854 | 0.86 | KDM4E (0.95) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL10780942 | 0.85 | KDM4E (0.84) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL28988364 | 0.85 | KDM4E (0.84) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL28084600 | 0.84 | KDM4E (0.91) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylhydroxamic Acid SCHEMBL16859850 | 0.82 | KDM4E (0.88) | KDM4EGAASMN1; SMN2MPOHIF1A | |
| Salicylic Acid SCHEMBL7299833 | 0.80 | HPGD (0.78) | KDM4EGAASMN1; SMN2MPOHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730201-B1 | Electronic tongue | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2004-05-04 | — | — | US | disclosed |