Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914211 | 0.82 | ELANE (0.71) | F2NPC1RAB9AELANEMAPT | |
| SCHEMBL17554141 | 0.81 | NPC1 (0.69) | F2NPC1RAB9AELANEMAPT | |
| SCHEMBL914337 | 0.75 | APEX1 (0.53) | NPC1RAB9AELANEMAPTALDH1A1 | |
| SCHEMBL6169453 | 0.74 | RAB9A (0.65) | NPC1RAB9AELANEMAPTALDH1A1 | |
| SCHEMBL15567401 | 0.73 | PTGES (0.43) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL6108114 | 0.72 | HDAC6 (0.55) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL1964870 | 0.71 | ELANE (0.61) | F2NPC1RAB9AELANEALDH1A1 | |
| SCHEMBL6171184 | 0.71 | RAB9A (0.72) | NPC1RAB9AELANEMAPTALDH1A1 | |
| SCHEMBL6170277 | 0.71 | MEN1 (0.60) | NPC1RAB9AELANEMAPTALDH1A1 | |
| SCHEMBL14462683 | 0.70 | NPC1 (0.55) | F2NPC1RAB9AELANEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |