Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.60 |
| ▸ | HTR3A | P46098 | 3/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029333 | 0.94 | HTR3A (0.67) | CHRNB2CHRNA4HTR3AHRH4ALDH1A1 | |
| SCHEMBL30824484 | 0.86 | HTR3A (0.73) | HTR3AHRH4ALDH1A1HSD17B10TDP1 | |
| SCHEMBL5508534 | 0.86 | HTR3A (0.73) | HTR3AHRH4ALDH1A1HSD17B10TDP1 | |
| SCHEMBL29648042 | 0.86 | HTR3A (0.73) | HTR3AHRH4ALDH1A1HSD17B10TDP1 | |
| Acetic Acid SCHEMBL27459452 | 0.85 | HTR3A (0.59) | HTR3AHRH4ALDH1A1USP2CYP1A2 | |
| SCHEMBL31691646 | 0.84 | HTR3A (0.71) | HTR3AHRH4ALDH1A1HSD17B10TDP1 | |
| SCHEMBL3776403 | 0.84 | HTR3A (0.71) | HTR3AHRH4ALDH1A1HSD17B10TDP1 | |
| SCHEMBL30120391 | 0.80 | HTR3A (0.50) | CHRNB2CHRNA4HTR3AHRH4ALDH1A1 | |
| SCHEMBL7595742 | 0.77 | HTR3A (0.52) | CHRNB2CHRNA4HTR3AHRH4ALDH1A1 | |
| SCHEMBL3551319 | 0.76 | HTR3A (0.69) | HTR3AHRH4CYP1A2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868707-B2 | Small molecule agonists of neurotensin receptor 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2018-01-16 | — | — | US | disclosed |
| US-20150329497-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | DUKE UNIVERSITY (US) | 2015-11-19 | — | — | US | disclosed |
| US-6821967-B2 | AMINES SUCH AS 9-(4-(4-(BENZOTHIAZOL-2-YL)-PIPERAZIN-1-YL)-BUTYL)-9H-FLUORENE-9-CARBOXYLIC ACID (2,2,2-TRIFLUOROETHYL) AMIDE, USED AS MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN ANTAGONISTS, TO PREVENT ATHEROSCLEROSIS OR HYPERLIPEMIA | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-11-23 | — | — | US | disclosed |
| US-20030166637-A1 | Substituted piperazine derivatives, the preparation thereofand their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-09-04 | — | — | US | disclosed |
| EP-0060081-B1 | PIPERAZINOQUINAZOLINE ANTIHYPERTENSIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND IMMUNOGENIC PROTEIN CONJUGATES FORMED FROM THEM | PFIZER INC. (US) | 1985-07-17 | — | — | EP | disclosed |
| US-4495188-A | HYPERTENSIVE AGENT | SANKYO COMPANY LIMITED (JP) | 1985-01-22 | — | — | US | disclosed |
| EP-0028473-B1 | CHLORO- AND ALKOXY-SUBSTITUTED-2,4-DIAMINOQUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1985-01-09 | — | — | EP | disclosed |
| EP-0053047-B1 | ACYLAMINOQUINAZOLINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1984-06-27 | — | — | EP | disclosed |
| US-4426382-A | HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1984-01-17 | — | — | US | disclosed |
| US-4426382-A | HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1984-01-17 | — | — | US | disclosed |
| US-4377581-A | ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4351940-A | Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0060081-A2 | Piperazinoquinazoline antihypertensives, processes for preparing them, pharmaceutical compositions containing them, and immunogenic protein conjugates formed from them | PFIZER INC. (US) | 1982-09-15 | — | — | EP | disclosed |
| EP-0053047-A1 | Acylaminoquinazoline derivatives, a process for their preparation and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-06-02 | — | — | EP | disclosed |
| US-4287341-A | USEFUL AS ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4171363-A | HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1979-10-16 | — | — | US | disclosed |
| US-4101548-A | HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1978-07-18 | — | — | US | disclosed |
| US-4001237-A | HYPOTENSIVES | BRISTOL-MYERS COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-4001238-A | HYPOTENSIVES | BRISTOL-MYERS COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166637-A1 | Substituted piperazine derivatives, the preparation thereofand their use as medicaments | MTTP, CETP, CPT1A | CHRNB2 4532/4885CHRNA4 4417/4885HTR3A 2835/4885 |
| US-20150329497-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | CHRNB2 55/4885CHRNA4 73/4885HTR3A 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.