Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771051 | 1.00 | PLA2G2A (0.44) | PLA2G2AHTR6EGFRIGF1RFLT4 | |
| SCHEMBL6776197 | 0.91 | PLA2G2A (0.46) | PLA2G2AHTR6EGFRIGF1RFLT4 | |
| SCHEMBL6699386 | 0.79 | HTR6 (0.67) | PLA2G2AHTR6 | |
| SCHEMBL6776017 | 0.77 | PLA2G2A (0.48) | PLA2G2AEGFRIGF1RFLT4KDR | |
| SCHEMBL818539 | 0.73 | PLA2G2A (0.59) | PLA2G2AHTR6 | |
| SCHEMBL29862561 | 0.73 | PLA2G2A (0.59) | PLA2G2AHTR6 | |
| SCHEMBL6771316 | 0.73 | PLA2G2A (0.49) | PLA2G2AEGFRIGF1RFLT4KDR | |
| SCHEMBL11838754 | 0.72 | HTR6 (0.56) | PLA2G2AHTR6 | |
| SCHEMBL11826084 | 0.72 | HTR6 (0.66) | PLA2G2AHTR6 | |
| SCHEMBL11826395 | 0.71 | HTR6 (0.53) | PLA2G2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |