Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 8/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770544 | 0.86 | RAB9A (0.55) | SERPINE1NPC1RAB9ATP53MAPT | |
| SCHEMBL16455939 | 0.80 | RAB9A (0.59) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL6105957 | 0.80 | NR1H4 (0.78) | SERPINE1NPC1RAB9ASMN1; SMN2PPARG | |
| SCHEMBL31261245 | 0.79 | RAB9A (0.58) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL22441103 | 0.79 | RAB9A (0.58) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL6773804 | 0.79 | F10 (0.65) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL6109346 | 0.78 | SERPINE1 (0.77) | SERPINE1NPC1MAPTPPARGNR1H4 | |
| SCHEMBL16496601 | 0.77 | SERPINE1 (0.75) | SERPINE1MAPTPPARGNR1H4PPARA | |
| SCHEMBL5693694 | 0.76 | SERPINE1 (0.65) | SERPINE1RAB9AMAPTPPARGNR1H4 | |
| SCHEMBL4429003 | 0.76 | KDM4C (0.54) | MAPTKDM4DKDM4CALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1140905-A1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039117-A1 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |