Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63113 | 0.97 | ACHE (0.65) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| Orcinol SCHEMBL8334005 | 0.85 | ACHE (0.78) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL29429337 | 0.81 | CYP3A4 (0.50) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL69242 | 0.81 | CYP3A4 (0.50) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL16857567 | 0.81 | ACHE (0.48) | ACHECYP3A4BACE1ALDH1A1TDP1 | |
| Propionaldehyde SCHEMBL28598922 | 0.77 | ACHE (0.44) | ACHECYP3A4ALDH1A1TDP1MEN1 | |
| SCHEMBL14087814 | 0.77 | ACHE (0.43) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL63577 | 0.77 | ACHE (0.43) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL7786855 | 0.77 | CYP3A4 (0.50) | ACHECYP3A4BACE1NQO1ALDH1A1 | |
| SCHEMBL69718 | 0.76 | ACHE (1.00) | ACHECYP3A4ALDH1A1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655359-B2 | Solid core microcapsular compositions and uses thereof | BOTANOCAP LTD. (IL) | 2017-05-23 | — | — | US | disclosed |
| US-20110268780-A1 | SOLID CORE MICROCAPSULAR COMPOSITIONS AND USES THEREOF | BOTANOCAP LTD. (IL) | 2011-11-03 | — | — | US | disclosed |