Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | HAT1 | O14929 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480809 | 0.77 | MAPT (0.71) | PBRM1MAPTTUBB1ALDH1A1HPGD | |
| SCHEMBL17023377 | 0.76 | MDH2 (0.72) | PBRM1MAOBALDH1A1HPGDMDH2 | |
| SCHEMBL6232289 | 0.72 | CA12 (0.45) | MAOBMAPTALDH1A1SMN1; SMN2ALPL | |
| SCHEMBL17034508 | 0.71 | HTT (0.53) | PBRM1MAPTTUBB1ALDH1A1HPGD | |
| SCHEMBL687294 | 0.70 | KMT2A (0.72) | MAOBMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6768371 | 0.70 | POLB (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29531272 | 0.70 | PBRM1 (1.00) | PBRM1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL50742 | 0.70 | PBRM1 (1.00) | PBRM1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL590922 | 0.69 | MAPT (0.73) | MAPTTUBB1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17025018 | 0.69 | PBRM1 (0.57) | PBRM1MAPTTUBB1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716605-B2 | Indole derivatives having an antiviral activity | SHIONOGI & CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-20030181499-A1 | Indole derivatives having an antiviral activity | FUJISHITA TOSHIO (JP) | 2003-09-25 | — | — | US | disclosed |
| US-6506787-B2 | Aids therapy | SHIONOGI & CO., LTD. (JP) | 2003-01-14 | — | — | US | disclosed |
| US-20020019434-A1 | Indole derivatives having an antiviral activity | FUJISHITA TOSHIO (JP) | 2002-02-14 | — | — | US | disclosed |
| US-6333323-B1 | AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV) DRUGS | SHIONOGI & CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1069111-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019434-A1 | Indole derivatives having an antiviral activity | IDO1, IDO2, RCOR1 | PBRM1 3220/4885MAOB 899/4885MAPT 4082/4885 |
| US-20030181499-A1 | Indole derivatives having an antiviral activity | IDO1, RCOR1, IDO2 | PBRM1 3281/4885MAOB 822/4885MAPT 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.