Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774009 | 1.00 | POLB (0.46) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6774017 | 0.90 | PLA2G2A (0.44) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6774011 | 0.90 | PLA2G2A (0.44) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6775267 | 0.82 | PLA2G2A (0.51) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6775272 | 0.82 | PLA2G2A (0.51) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6776182 | 0.80 | PLA2G2A (0.44) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6777313 | 0.80 | PLA2G2A (0.44) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL7965269 | 0.78 | PLA2G2A (0.60) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6781949 | 0.77 | PLA2G2A (0.42) | POLBUSP2ALDH1A1HSD17B10PLA2G2A | |
| SCHEMBL6781671 | 0.75 | PLA2G2A (0.49) | PLA2G2AMTNR1AMTNR1BICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-0950661-B1 | Substituted tricyclics useful in sPLA2 induced diseases | LILLY CO ELI (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1156050-A2 | Substituted tricyclics useful in sPLA2 induced diseases | ELI LILLY AND COMPANY (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |