Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 11/20 | 0.60 |
| ▸ | ICMT | O60725 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775267 | 0.91 | PLA2G2A (0.51) | PLA2G2AICMTTDP1MTNR1AMTNR1B | |
| SCHEMBL6775272 | 0.91 | PLA2G2A (0.51) | PLA2G2AICMTTDP1MTNR1AMTNR1B | |
| SCHEMBL7961599 | 0.79 | PLA2G2A (0.76) | PLA2G2AICMT | |
| SCHEMBL7964192 | 0.79 | PLA2G2A (0.76) | PLA2G2AICMTPLA2G10 | |
| SCHEMBL6776182 | 0.78 | PLA2G2A (0.44) | PLA2G2AICMTMTNR1AMTNR1BUSP2 | |
| SCHEMBL6774016 | 0.78 | POLB (0.46) | PLA2G2AICMTMTNR1AMTNR1BUSP2 | |
| SCHEMBL6774011 | 0.78 | PLA2G2A (0.44) | PLA2G2AICMTMTNR1AMTNR1BUSP2 | |
| SCHEMBL6774009 | 0.78 | POLB (0.46) | PLA2G2AICMTMTNR1AMTNR1BUSP2 | |
| SCHEMBL6777313 | 0.78 | PLA2G2A (0.44) | PLA2G2AICMTMTNR1AMTNR1BUSP2 | |
| SCHEMBL6774017 | 0.78 | PLA2G2A (0.44) | PLA2G2AICMTMTNR1AMTNR1BUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |