Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27567992 | 0.86 | MAPK14 (0.38) | SLC6A4SLC6A3PKLRHSD17B10TSHR | |
| SCHEMBL5281418 | 0.82 | KDM4E (0.35) | NOTUMIL2KDM4EHSD17B10NPC1 | |
| SCHEMBL6784280 | 0.81 | NOTUM (0.40) | NOTUMKDM4ESLC6A4SLC6A3PKLR | |
| Formic Acid SCHEMBL6783270 | 0.78 | KDM4E (0.33) | NOTUMKDM4EMAPK1 | |
| SCHEMBL6783272 | 0.78 | KDM4E (0.32) | KDM4EMAPK1 | |
| SCHEMBL6774260 | 0.78 | PDK2 (0.41) | KDM4ESLC6A4SLC6A3HSD17B10NPC1 | |
| SCHEMBL6778213 | 0.76 | ALDH1A1 (0.37) | NOTUMKDM4EPKLRHSD17B10TSHR | |
| SCHEMBL8057061 | 0.76 | KDM4E (0.36) | KDM4ESLC6A3PKLRHSD17B10TSHR | |
| SCHEMBL8060698 | 0.75 | KDM4E (0.36) | KDM4ESLC6A3PKLRHSD17B10TSHR | |
| SCHEMBL6775145 | 0.75 | CYP46A1 (0.41) | KDM4EHSD17B10TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1630649-A | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid | AVENTIS PHARMACEUTICAL GERMANY (DE) | 2005-06-22 | — | — | CN | disclosed |
| US-6730697-B2 | FOR USE AS ANTIARRYTHMIC MEDICAMENTS WITH A CARDIOPROTECTIVE COMPONENT FOR PROPHYLAXIS OF AN INFARCTION AND THERAPY OF INFARCTION, AND FOR TREATMENT OF ANGINA PECTORIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-04 | — | — | US | disclosed |