Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5277022 | 0.87 | THRB (0.36) | KDM4EMAPTTP53THRBMEN1 | |
| SCHEMBL6774138 | 0.82 | NOTUM (0.37) | KDM4ENOTUMMAPK1KMT2ANPC1 | |
| SCHEMBL5282508 | 0.81 | KDM4E (0.40) | KDM4ENOTUMMAPK1MAPTTP53 | |
| SCHEMBL5288509 | 0.79 | KMT2A (0.36) | KDM4EMAPTPIK3CDPIK3R2PIK3CA | |
| SCHEMBL5285655 | 0.76 | MAPT (0.33) | KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL5277972 | 0.74 | MAPT (0.38) | KDM4EMAPTPIK3CDPIK3R2PIK3CA | |
| SCHEMBL5279300 | 0.74 | KMT2A (0.40) | MAPTMEN1KMT2ALMNAHSD17B10 | |
| SCHEMBL5280563 | 0.74 | KMT2A (0.38) | KDM4EMAPK1MAPTMEN1KMT2A | |
| SCHEMBL5281217 | 0.71 | NCEH1 (0.34) | KDM4EMAPTMEN1KMT2ALMNA | |
| SCHEMBL6783272 | 0.70 | KDM4E (0.32) | KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474414-B1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1474414-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | Aventis Pharma Deutschland GmbH (DE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066620-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-08-14 | — | — | WO | disclosed |