Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775016 | 0.88 | PIK3R1 (0.50) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6765561 | 0.86 | ALDH1A1 (0.59) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6770039 | 0.84 | PIK3R1 (0.52) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6775433 | 0.84 | ADORA2A (0.56) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL6769328 | 0.82 | ADORA1 (0.50) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6768956 | 0.82 | ADORA2A (0.46) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL6768976 | 0.79 | ADORA2A (0.60) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6768993 | 0.79 | ADORA2A (0.48) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 | |
| SCHEMBL6768530 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL6769161 | 0.79 | ADORA2A (0.46) | PIK3R1PIK3CAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750232-B2 | ADENOSINE ANTAGONIST; AN IMPORTANT REGULATORY FACTOR INVOLVED IN VARIOUS INTRACELLULAR METABOLISMS SUCH AS REGULATION OF ENERGY LEVELS | EISAI CO., LTD. (JP) | 2004-06-15 | — | — | US | disclosed |
| US-20040006082-A1 | 2-Aminopyridine compounds and use thereof as drugs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-01-08 | — | — | US | disclosed |
| EP-1308441-A1 | 2-AMINOPYRIDINE COMPOUNDS AND USE THEREOF AS DRUGS | Eisai Co., Ltd. (JP) | 2003-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006082-A1 | 2-Aminopyridine compounds and use thereof as drugs | ADORA1, ADORA2B, ADORA2A | PIK3R1 1476/4885PIK3CA 1459/4885ALDH1A1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.