Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.38 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054685 | 0.84 | MAPT (0.38) | LMNATHRBPIK3CDPIK3R2PIK3CA | |
| SCHEMBL6775086 | 0.80 | ACHE (0.39) | THRBPIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL6779321 | 0.79 | PIK3CD (0.38) | LMNATHRBPIK3CDPIK3R2PIK3CA | |
| SCHEMBL12746154 | 0.71 | VEGFA (0.40) | LMNATHRBPIK3CDPIK3R2PIK3CA | |
| SCHEMBL19602438 | 0.71 | VEGFA (0.50) | LMNAPIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL12746150 | 0.69 | VEGFA (0.40) | LMNATHRBALKBH3MAOAMAOB | |
| SCHEMBL1610760 | 0.65 | GPR3 (0.44) | NFKBIARELASLC40A1MAOAMAOB | |
| SCHEMBL8256013 | 0.64 | CES1 (0.34) | LMNACES1 | |
| SCHEMBL4403141 | 0.63 | METAP1 (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL10164110 | 0.62 | CES1 (0.39) | CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730697-B2 | FOR USE AS ANTIARRYTHMIC MEDICAMENTS WITH A CARDIOPROTECTIVE COMPONENT FOR PROPHYLAXIS OF AN INFARCTION AND THERAPY OF INFARCTION, AND FOR TREATMENT OF ANGINA PECTORIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-04 | — | — | US | disclosed |