SCHEMBL6774776

SCHEMBL6774776

Cc1c(O)c2ccccc2c2nc(Nc3cccc(CC=NNC(=N)N)c3)sc12

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.46
PTGS2 P35354 1/20 0.46
AURKA O14965 2/20 0.33
AURKB Q96GD4 2/20 0.33
TBXAS1 P24557 3/20 0.33
ALOX5 P09917 2/20 0.33
LTB4R Q15722 2/20 0.33
SIGMAR1 Q99720 1/20 0.32
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
KMT2A Q03164 1/20 0.31
TOP2A P11388 1/20 0.31
TOP2B Q02880 1/20 0.31
PLAU P00749 1/20 0.31
ADORA2A P29274 1/20 0.31
ABCG2 Q9UNQ0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6774778 0.88 PTGS1 (0.44) PTGS1PTGS2AURKAAURKBTBXAS1
SCHEMBL6074447 0.80 PLK4 (0.43) PTGS1PTGS2AURKAAURKBMEN1
SCHEMBL6074435 0.80 PLK4 (0.43) PTGS1PTGS2AURKAAURKBMEN1
Hydrochloric Acid SCHEMBL6074379 0.79 PLK4 (0.42) PTGS1PTGS2AURKAAURKBMEN1
Hydrochloric Acid SCHEMBL6074385 0.79 PLK4 (0.42) PTGS1PTGS2AURKAAURKBMEN1
Hydrochloric Acid SCHEMBL6074903 0.72 MEN1 (0.50) PTGS1PTGS2MEN1LMNAKMT2A
SCHEMBL6074466 0.71 PTGS1 (0.39) PTGS1PTGS2MEN1KMT2A
Hydrochloric Acid SCHEMBL6074390 0.70 PTGS1 (0.39) PTGS1PTGS2MEN1KMT2A
Hydrochloric Acid SCHEMBL6743159 0.67 KMT2A (0.50) PTGS1PTGS2ALOX5MEN1LMNA
Hydrochloric Acid SCHEMBL6074699 0.66 PTGS1 (0.57) PTGS1PTGS2TBXAS1ALOX5LTB4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6777557-B2 Method and composition for rejuvenating cells, tissues organs, hair and nails FARRINGTON PHARMACEUTICALS, LLC 2004-08-17 US disclosed
US-20020188015-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails FARRINGTON PHARMACEUTICALS, LLC 2002-12-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020188015-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails TERT, TELO2, HKDC1 PTGS1 4108/4885PTGS2 4133/4885AURKA 2995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.