Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775113 | 0.79 | MAPKAPK2 (0.41) | MAPKAPK2LTB4R2ROCK2SLC6A2SLC6A4 | |
| SCHEMBL6779730 | 0.77 | GPBAR1 (0.44) | GPBAR1KMT2AGAATSHR | |
| SCHEMBL6773913 | 0.77 | LTB4R2 (0.41) | MAPKAPK2LTB4R2ROCK2PDK1 | |
| SCHEMBL6785514 | 0.76 | LTB4R2 (0.46) | MAPKAPK2LTB4R2GPBAR1KMT2APDK1 | |
| SCHEMBL6774316 | 0.75 | ALDH1A1 (0.51) | MAPKAPK2LTB4R2KMT2AGAAPDK1 | |
| SCHEMBL6775891 | 0.73 | PDK1 (0.47) | LTB4R2KMT2AGAATSHRPDK1 | |
| SCHEMBL6780805 | 0.72 | KMT2A (0.47) | LTB4R2KMT2AMAPK14 | |
| SCHEMBL6778429 | 0.72 | MAPT (0.50) | LTB4R2SLC6A2SLC6A4PDK1 | |
| SCHEMBL6783999 | 0.72 | PTGER1 (0.47) | LTB4R2PDK1 | |
| SCHEMBL6779984 | 0.72 | NPY2R (0.44) | MAPKAPK2LTB4R2GPBAR1MAPK14PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780883-B2 | ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTILIPEMIC AGENTS; RESTENOSIS; DIETETICS | WARNER-LAMBERT COMPANY | 2004-08-24 | — | — | US | claimed |