SCHEMBL6775253

SCHEMBL6775253

COc1nc2ccccc2c2c1C(=O)c1cnccc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
MAPT P10636 4/20 0.44
FGFR1 P11362 1/20 0.41
SRC P12931 1/20 0.41
FGFR2 P21802 1/20 0.41
FGFR4 P22455 1/20 0.41
FGFR3 P22607 1/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 3/20 0.40
GAA P10253 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CCNE2 O96020 1/20 0.39
CDK4 P11802 1/20 0.39
CCND1 P24385 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5784090 0.81 KEAP1 (0.49) MAOAMAOBMEN1KMT2AALDH1A1
SCHEMBL6477402 0.77 KEAP1 (0.50) MAOAMAOBMEN1KMT2AALDH1A1
SCHEMBL9041017 0.73 MAPT (0.49) MAPTMEN1KMT2AALDH1A1GAA
SCHEMBL16895265 0.73 MAPK1 (0.45) MAPTMEN1KMT2AALDH1A1GUSB
SCHEMBL9041856 0.72 MAPT (0.55) MAPTMEN1KMT2AALDH1A1GAA
SCHEMBL20259195 0.72 MAOA (0.49) MAOAMAOBMAPTFGFR1SRC
SCHEMBL5780878 0.72 TOP1 (0.61) ALDH1A1GAAPOLB
SCHEMBL6776178 0.72 MAOA (0.56) MAOAMAOBMAPTFGFR1SRC
SCHEMBL6517892 0.71 PRNP (0.45) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL6482857 0.70 TOP1 (0.49) MAPTKMT2AALDH1A1CYP3A4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6680326-B2 ANTITUMOR AGENTS; ANTICANCER AGENTS HOFFMANN-LA ROCHE INC. 2004-01-20 US disclosed