Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.52 |
| ▸ | ESR1 | P03372 | 13/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.52 |
| ▸ | TOP1 | P11387 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511425 | 0.92 | HRAS (0.63) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6780445 | 0.91 | KDM4E (0.63) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7504279 | 0.85 | HRAS (0.44) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6776130 | 0.83 | KDM4E (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7501738 | 0.79 | HRAS (0.59) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL21277951 | 0.79 | HRAS (0.63) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL3454590 | 0.78 | HRAS (0.50) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6780841 | 0.78 | HRAS (0.50) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL16469479 | 0.78 | HRAS (0.61) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6175427 | 0.77 | KDM4E (0.62) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753316-B1 | 3-ACRYLAMIDOPYRAZOLE-5-CARBOXAMIDE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-06-22 | — | — | US | disclosed |