Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.61 |
| ▸ | ESR1 | P03372 | 13/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.61 |
| ▸ | TOP1 | P11387 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6175427 | 0.99 | KDM4E (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7510361 | 0.90 | HRAS (0.76) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL9124388 | 0.89 | KDM4E (0.76) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6548715 | 0.89 | KDM4E (0.76) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL10688614 | 0.89 | KDM4E (0.76) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6497712 | 0.89 | KDM4E (0.59) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL21277951 | 0.89 | HRAS (0.63) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6777006 | 0.89 | KDM4E (0.52) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14573086 | 0.88 | HRAS (0.62) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6176662 | 0.87 | KDM4E (0.58) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587426-B1 | NEW ALKYLATING AGENTS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2022-08-10 | — | — | EP | disclosed |
| EP-2836494-B1 | NEW ALKYLATING AGENTS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-08-21 | — | — | EP | disclosed |
| US-10071074-B2 | Thieno-indole moieties and methods of treating using the same | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2018-09-11 | — | — | US | disclosed |
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-03-16 | — | — | US | disclosed |
| US-9527863-B2 | Thieno-indole moieties and methods of treating using the same | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-12-27 | — | — | US | disclosed |
| US-20150051154-A1 | ALKYLATING AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | INMT, TYMP, TOP1 | HRAS 2418/4885ESR1 4458/4885ESR2 4559/4885 |
| US-10071074-B2 | Thieno-indole moieties and methods of treating using the same | INMT, TOP2B, TOP1 | HRAS 3423/4885ESR1 3302/4885ESR2 3066/4885 |
| US-20150051154-A1 | ALKYLATING AGENTS | PCNA, TOP1, TYMP | HRAS 1344/4885ESR1 4625/4885ESR2 4620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.