Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 10/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770388 | 0.93 | PLA2G2A (0.41) | PLA2G2APLA2G1BPTPN1CA1CA2 | |
| SCHEMBL6692861 | 0.89 | PLA2G2A (0.46) | PLA2G2APLA2G1BPLA2G10BCL2BCL2L1 | |
| SCHEMBL6694433 | 0.89 | PLA2G2A (0.46) | PLA2G2APLA2G1BPLA2G10ADRA1DPARP1 | |
| SCHEMBL6775713 | 0.89 | PLA2G2A (0.43) | PLA2G2APLA2G1BPLA2G10BCL2BCL2L1 | |
| SCHEMBL6774933 | 0.88 | PLA2G2A (0.42) | PLA2G2APLA2G1BPTPN1PLA2G10ACMSD | |
| SCHEMBL6777361 | 0.88 | PLA2G2A (0.46) | PLA2G2APLA2G1BPLA2G10PARP1PLA2G5 | |
| SCHEMBL6776234 | 0.88 | PLA2G2A (0.47) | PLA2G2APLA2G1BPLA2G10BCL2BCL2L1 | |
| SCHEMBL6895052 | 0.88 | PLA2G1B (0.42) | PLA2G2APLA2G1BPTPN1HSP90AA1 | |
| SCHEMBL6775731 | 0.87 | PLA2G2A (0.46) | PLA2G2APLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL6770631 | 0.87 | PLA2G2A (0.46) | PLA2G2APLA2G1BPLA2G10ACMSDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |