Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 14/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 10/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.39 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.39 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.39 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.39 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771677 | 0.93 | PLA2G2A (0.41) | PLA2G2APLA2G10ACMSDSLCO1B1PLA2G1B | |
| SCHEMBL6770631 | 0.92 | PLA2G2A (0.46) | PLA2G2APLA2G10ACMSDPLA2G1BF10 | |
| SCHEMBL6694433 | 0.92 | PLA2G2A (0.46) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL6775943 | 0.90 | PLA2G2A (0.49) | PLA2G2APLA2G10ACMSDSLCO1B1HNF4A | |
| SCHEMBL6773103 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL6776217 | 0.88 | PLA2G2A (0.44) | PLA2G2APLA2G10ACMSDSLCO1B1PLA2G1B | |
| SCHEMBL6775875 | 0.88 | PLA2G2A (0.40) | PLA2G2APLA2G10PLA2G1BF10 | |
| SCHEMBL6773052 | 0.88 | PLA2G2A (0.50) | PLA2G2APLA2G1BF10 | |
| SCHEMBL6774185 | 0.88 | TP53 (0.47) | PLA2G2APLA2G1BF10KLKB1KLK1 | |
| SCHEMBL6770537 | 0.88 | FABP3 (0.41) | PLA2G2APLA2G10PLA2G1BF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |