Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777431 | 0.89 | PARP1 (0.41) | PPARGF10CNR2CTRB1 | |
| SCHEMBL5212214 | 0.89 | PPARG (0.46) | PPARGAGTR1AGTR2PPARA | |
| SCHEMBL6897889 | 0.89 | CNR2 (0.38) | PPARGAGTR1AGTR2CNR2PLA2G4A | |
| SCHEMBL6776640 | 0.87 | CETP (0.41) | PPARGPPARA | |
| SCHEMBL6776320 | 0.87 | PPARG (0.41) | PPARGCNR2PPARA | |
| SCHEMBL6781319 | 0.87 | PPARG (0.42) | PPARGAGTR1AGTR2F10CNR2 | |
| SCHEMBL6770304 | 0.87 | CNR1 (0.42) | PPARGF10CNR2PPARA | |
| SCHEMBL6778112 | 0.86 | PPARG (0.40) | PPARGF10CNR2 | |
| SCHEMBL6775871 | 0.86 | LMNA (0.40) | PPARGF10CNR2PPARA | |
| SCHEMBL6773827 | 0.86 | PPARG (0.39) | PPARGAGTR1AGTR2F10PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |