Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.38 |
| ▸ | MDH1 | P40925 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889596 | 0.91 | SLC6A2 (0.40) | CNR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5212605 | 0.90 | MAPK8 (0.42) | AGTR1AGTR2PLA2G4APPARG | |
| SCHEMBL6776370 | 0.89 | PPARG (0.44) | CNR2AGTR1AGTR2PLA2G4APPARG | |
| SCHEMBL6897075 | 0.89 | CETP (0.41) | PPARG | |
| SCHEMBL6894406 | 0.88 | MAPK8 (0.42) | CNR2SLC6A3 | |
| SCHEMBL6889205 | 0.88 | MAPK8 (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL6888047 | 0.88 | CNR1 (0.38) | CNR2AGTR1AGTR2PPARG | |
| SCHEMBL6896800 | 0.87 | MAPT (0.43) | CNR2AGTR1 | |
| SCHEMBL6891901 | 0.86 | PLA2G2A (0.43) | CNR2AGTR1 | |
| SCHEMBL6889327 | 0.86 | MAPT (0.41) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |