Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31188635 | 1.00 | ALOX5 (0.57) | ALOX5MAOAMAOBLTA4HPLA2G2A | |
| SCHEMBL329575 | 0.86 | ALOX5 (0.62) | ALOX5MAOAMAOBLTA4HPLA2G2A | |
| Indole SCHEMBL15320969 | 0.85 | ALOX5 (0.61) | ALOX5MAOAMAOBLTA4HPLA2G2A | |
| SCHEMBL12938497 | 0.84 | ALOX5 (0.78) | ALOX5MAOAMAOBLTA4HPLA2G2A | |
| SCHEMBL9525385 | 0.82 | ALOX5 (0.53) | ALOX5MAOAMAOBRAB9ANPC1 | |
| SCHEMBL19234842 | 0.81 | MAOB (0.56) | ALOX5MAOAMAOBLTA4H | |
| SCHEMBL25422318 | 0.81 | AHR (0.54) | MAOAMAOBLTA4H | |
| SCHEMBL30488431 | 0.81 | AHR (0.54) | MAOAMAOBLTA4H | |
| SCHEMBL14543024 | 0.81 | NR4A2 (0.54) | MAOAMAOBLTA4HHDAC1 | |
| SCHEMBL30376216 | 0.81 | MAOB (0.47) | MAOAMAOBLTA4HRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | claimed |
| US-6750242-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2004-06-15 | — | — | US | disclosed |
| EP-1230216-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032619-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |