Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450443 | 0.93 | PDE5A (0.49) | PDE5ATERTMAPTPOLBKMT2A | |
| SCHEMBL6777123 | 0.86 | PDE5A (0.47) | PDE5ATERTMAPK8ALDH1A1 | |
| SCHEMBL6356953 | 0.84 | TERT (0.57) | PDE5ATERTMAPTPOLBKMT2A | |
| SCHEMBL3579254 | 0.83 | PDE5A (0.46) | PDE5ATERTMAPTPOLBKMT2A | |
| SCHEMBL6447286 | 0.83 | MEN1 (0.39) | PDE5APOLBKMT2AMEN1RAB9A | |
| SCHEMBL6442714 | 0.78 | PDE5A (0.52) | PDE5ATERTKMT2AMEN1CCNA2 | |
| SCHEMBL6446169 | 0.78 | PDE5A (0.67) | PDE5APOLBKMT2AMEN1CDK2 | |
| SCHEMBL6444664 | 0.77 | PDE5A (0.74) | PDE5AKMT2AALDH1A1KDM4E | |
| SCHEMBL6776102 | 0.77 | PDE5A (0.39) | PDE5ATERTMAPK8 | |
| SCHEMBL6772078 | 0.74 | MAPT (0.46) | MAPTPOLBKMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |