Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | TERT | O14746 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777230 | 0.91 | PDE5A (0.33) | PDE5ATERTUSP2TSHRPRKD3 | |
| SCHEMBL6777123 | 0.81 | PDE5A (0.47) | PDE5ATERTTSHRPRKD3MAPK8 | |
| SCHEMBL6776964 | 0.77 | PDE5A (0.44) | PDE5ATERTMAPK8 | |
| SCHEMBL6746112 | 0.74 | PDE5A (0.42) | PDE5ATERTIRAK4 | |
| SCHEMBL6895181 | 0.73 | TERT (0.60) | PDE5ATERT | |
| SCHEMBL6446169 | 0.73 | PDE5A (0.67) | PDE5ATSHR | |
| SCHEMBL6442714 | 0.72 | PDE5A (0.52) | PDE5ATERTTSHRIRAK4 | |
| SCHEMBL6444664 | 0.72 | PDE5A (0.74) | PDE5A | |
| SCHEMBL2402678 | 0.70 | PDE5A (0.53) | PDE5A | |
| SCHEMBL6450443 | 0.69 | PDE5A (0.49) | PDE5ATERTMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |