Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699063 | 0.90 | ADRA1D (0.49) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6772821 | 0.89 | ADRA1D (0.44) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6896662 | 0.88 | KLKB1 (0.44) | KLKB1KLK1CCR2FEN1IDH1 | |
| SCHEMBL6772182 | 0.87 | ADRA1D (0.43) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6691732 | 0.87 | ADRA1D (0.44) | ADRA1DMAPK8FEN1PLA2G2APOLB | |
| SCHEMBL6774631 | 0.87 | ADRA1D (0.44) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6690357 | 0.86 | PLA2G2A (0.51) | PLA2G2APOLB | |
| SCHEMBL6776550 | 0.85 | ADRA1D (0.41) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6775268 | 0.85 | ADRA1D (0.48) | KLKB1KLK1ADRA1DMAPK8CCR2 | |
| SCHEMBL6775492 | 0.85 | PLA2G2A (0.41) | KLKB1MAPK8FEN1PLA2G2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |