Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775145 | 0.90 | CYP46A1 (0.41) | CYP46A1NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL27567996 | 0.88 | ABL1 (0.41) | NR4A2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL6774260 | 0.88 | PDK2 (0.41) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL6784280 | 0.86 | NOTUM (0.40) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5285655 | 0.81 | MAPT (0.33) | KDM4EHPGDTDP1MAPTHSD17B10 | |
| SCHEMBL27567994 | 0.81 | KMT2A (0.41) | NR4A2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL14342070 | 0.80 | F2 (0.33) | MAPT | |
| SCHEMBL6778213 | 0.79 | ALDH1A1 (0.37) | NR4A2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8057061 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL8060698 | 0.78 | KDM4E (0.36) | KDM4EALDH1A1HPGDMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1319963-C | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid | AVENTIS PHARMACEUTICAL GERMANY (DE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1630649-A | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid | AVENTIS PHARMACEUTICAL GERMANY (DE) | 2005-06-22 | — | — | CN | disclosed |
| US-6730697-B2 | FOR USE AS ANTIARRYTHMIC MEDICAMENTS WITH A CARDIOPROTECTIVE COMPONENT FOR PROPHYLAXIS OF AN INFARCTION AND THERAPY OF INFARCTION, AND FOR TREATMENT OF ANGINA PECTORIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-04 | — | — | US | disclosed |